前列腺跨膜上皮1抗原抗体
规格：1mg/1ml
英文名： STEAP1
别名： Six transmbrane epithelial antigen of the prostate; MGC19484; PRSS 24; PRSS24; Six transmembrane epithelial antigen of the prostate; STEAP 1; STEAP1; STEA1_HUMAN.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human STEAP1
交叉反应：Human, Mouse, Rat, Cow, Horse,
细胞定位：细胞浆 细胞膜
前列腺跨膜上皮1抗原抗体产品介绍：background: This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell cell junctions. Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer 前列腺跨膜上皮1抗原抗体markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines. Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. 前列腺跨膜上皮1抗原抗体Subcellular Location: Endosome membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitously expressed. Highly expressed in prostate tumors. Similarity: Belongs to the STEAP family. Contains 1 ferric oxidoreductase domain. Gene ID: 26872 Database links: Entrez Gene: 26872 Human Entrez Gene: 297738 Rat Omim: 604415 Human SwissProt: Q9UHE8 Human Unigene: 61635 Human Unigene: 51773 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
前列腺跨膜上皮1抗原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 上皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid