NAGPA蛋白抗体
规格：1mg/1ml
英文名： NAGPA
别名： Mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; NAGPA; NAGPA_HUMAN; Phosphodiester alpha-GlcNAcase.
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NAGPA
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：
NAGPA蛋白抗体产品介绍：background: Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008] Function: Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Subunit: Homotetramer arranged as two NAGPA蛋白抗体disulfide-linked homodimers Subcellular Location: Golgi apparatus > Golgi stack membrane. Cis/medial Golgi. Tissue Specificity: Isoform 2 may be brain-specific. Post-translational modifications: The precursor is cleaved and activated in the trans-Golgi network by a furin endopeptidase. Similarity: Contains 1 EGF-like domain. Gene ID: 51172 Database links: Entrez Gene: 515935 Cow Entrez Gene: 490019 Dog Entrez Gene:NAGPA蛋白抗体 100723215 Guinea pig Entrez Gene: 100069983 Horse Entrez Gene: 51172 Human Entrez Gene: 27426 Mouse Entrez Gene: 100512596 Pig Entrez Gene: 360476 Rat Omim: 607985 Human SwissProt: P68827 Cow SwissProt: Q9UK23 Human SwissProt: Q8BJ48 Mouse Unigene: 21334 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NAGPA蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid