NACAD蛋白抗体
规格：1mg/1ml
英文名： NACAD
别名： KIAA0363; NAC-alpha domain-containing protein 1; NACAD; NACAD_HUMAN.
分子量： 161kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NACAD
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,
细胞定位：细胞核 细胞浆
NACAD蛋白抗体产品介绍：background: NACAD is a 1,562 amino acid protein that prevents non-secretory polypeptides from targeting the endoplasmic reticulum. Localizing to both the cytoplasm and nucleus, NACAD belongs to the NAC-alpha family and contains one NAC-A/B (NAC-alpha/beta) domain. The gene encoding NACAD maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. Function: NACAD蛋白抗体May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). NACAD蛋白抗体Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the NAC-alpha family. Contains 1 NAC-A/B (NAC-alpha/beta) domain. Gene ID: 23148 Database links: Entrez Gene: 23148 Human SwissProt: O15069 Human Unigene: 96633 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NACAD蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid