肌凝蛋白磷酸酶2抗体
规格：1mg/1ml
英文名： Myosin Phosphatase 2
别名： Myosin Phosphatase 2; Myosin phosphatase regulatory subunit; Myosin phosphatase targeting subunit 2; Myosin phosphatase, target subunit 2; MYPT2; PP1bp55; PPP1R12B; Protein phosphatase 1 regulatory su
分子量： 110 kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Myosin P
交叉反应：Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit,
细胞定位：细胞浆
肌凝蛋白磷酸酶2抗体产品介绍：background: Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011] Function: Regulates myosin phosphatase activity. Augments Ca2+ sensitivity of the contractile apparatus. Subunit: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or肌凝蛋白磷酸酶2抗体 regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16. Subcellular Location: Cytoplasm. Tissue Specificity: Detected in skeletal muscle, fetal and ***** 肌凝蛋白磷酸酶2抗体heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. Similarity: Contains 5 ANK repeats. Gene ID: 4660 Database links: Entrez Gene: 4660 Human Entrez Gene: 329251 Mouse Omim: 603768 Human SwissProt: O60237 Human Unigene: 444403 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌凝蛋白磷酸酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid