髓细胞/**细胞或混合谱系白血病蛋白6抗体
规格：1mg/1ml
英文名： MLLT6
别名： AF 17; AF17; AF17_HUMAN; ALL1-fused gene from chromosome 17 protein; FLJ23480; MLLT 6; MLLT6; Myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog) translocated to 6; Myeloid/lym
分子量： 125kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MLLT6
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞核
髓细胞/**细胞或混合谱系白血病蛋白6抗体产品介绍：background: The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10% of patients with acute lymphoblastic leukemia (ALL) and 5% of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. The gene encoding MLLT6, also known as mixed-lineage leukemia translocated to 6 or AF17, is located on chromosome 17q12 and encodes a 1093 amino acid protein that is thought to be involved in the translocations on chromosome 11q23. Localized to the nucleus, MLLT6 contains a leucine-zipper dimerization motif located 3-prime of the fusion point and a cysteine-rich domain at the C-terminus.髓细胞/**细胞或混合谱系白血病蛋白6抗体 MLLT6 is thought to play a role in ALL by repressing the activity of the truncated ALL1 protein. Subcellular Location: Nucleus. DISEASE: Note=A chromosomal aberration involving MLLT6 is associated with acute leukemias. Translocation t(11;17)(q23;q21) with MLL/HRX. The result is a rogue activator protein. Similarity: Contains 2 PHD-type zinc fingers. Database links: 髓细胞/**细胞或混合谱系白血病蛋白6抗体Entrez Gene: 4302 Human Entrez Gene: 246198 Mouse Entrez Gene: 303504 Rat Omim: 600328 Human SwissProt: P55198 Human Unigene: 91531 Human Unigene: 23685 Mouse Unigene: 222490 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
髓细胞/**细胞或混合谱系白血病蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 **细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid