MITD1蛋白抗体
规格：1mg/1ml
英文名： MITD1
别名： Microtubule interacting and transport domain containing 1; MIT; MIT domain containing protein 1; MIT microtubule interacting and transport domain containing 1; MITD 1.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
MITD1蛋白抗体**原：KLH conjugated synthetic peptide derived from human MITD1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, Cat,
细胞定位：细胞浆 细胞膜
产品介绍：background: MITD1 is a 249 amino acid peripheral membrane protein that localizes to the cytoplasmic side of late endosomes, where it is Implicated in endosomal protein transport. MITD1 interacts with CHMP2 and CHMP1B, and is encoded by a gene that maps to human chromosome 2q11.2. As the second largest human chromosome, chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorderMITD1蛋白抗体 sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome is due to mutations in the ALMS1 gene. Function: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. Subunit: Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1. Subcellular Location: Late endosome MITD1蛋白抗体membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Similarity: Contains 1 MIT domain. Database links: Entrez Gene: 129531 Human Entrez Gene: 69028 Mouse Entrez Gene: 363219 Rat SwissProt: Q8WV92 Human SwissProt: Q8VDV8 Mouse SwissProt: Q5I0J5 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MITD1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid