中胚层诱导早期反应蛋白3抗体
规格：1mg/1ml
英文名： MIER3
别名： DKFZp686L09111; DKFZp781G1119; DKFZP781I1119; FLJ35954; Mesoderm induction early response 1 family member 3; Mesoderm induction early response protein 3; Mi-er3; MIER 3; MIER3; MIER3_HUMAN.
分子量： 61kDa
产品介绍MSDS与**信息质检证书(CoA)相关产品
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIER3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Ferret, Baboon, Rhesus monkey, Gorilla, Orangutan
细胞定位：细胞核
中胚层诱导早期反应蛋白3抗体产品介绍：background: The mesoderm induction early response (MIER) protein family (also known as the fibroblast growth factor (FGF)-regulated immediate-early protein family) comprises a group of proteins that are activated by FGF (fibroblast growth factor). This suggests that MEIR proteins may play a significant role in FGF-regulated cellular activities and in the progression of certain cancers. MIER proteins contain one SANT domain, which is involved in transcriptional activation and repression, and one ELM2 domain, which was first characterized in egl-27, a gene that is critically involved in embryonic patterning of C. elegans. MIER1, formerly known as early response 1 (ER1), was first cloned and characterized in Xenopus. Expression of MIER1 is negligible in most normal tissues, but has been found to be upregulated in breast carcinoma cell lines and tumors. MIER1 functions as a transcriptional repressor of a number of genes including Sp1 target genes, most likely through interaction with HDAC1. Function: Transcriptional repressor regulating the expression of a number of genes including SP1 target genes.中胚层诱导早期反应蛋白3抗体 Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. Subunit: Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. Subcellular Location: Nucleus; Cytoplasm Tissue Specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. Similarity: Contains 1 ELM2 domain. Contains 1 SANT domain. 中胚层诱导早期反应蛋白3抗体Database links: Entrez Gene: 166968 Human SwissProt: Q7Z3K6 Human SwissProt: Q7Z3K6-1 Human SwissProt: Q7Z3K6-2 Human SwissProt: Q7Z3K6-3 Human SwissProt: Q7Z3K6-4 Human SwissProt: Q7Z3K6-5 Human Unigene: 657594 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
中胚层诱导早期反应蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 生长因子和** 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid