ERK2结合睾丸蛋白1抗体
规格：1mg/1ml
英文名： MICALCL
别名： Ebitein-1; EBITEIN1; ERK2-binding testicular protein 1; FLJ14966; MICAL C-terminal-like protein; Micalcl; MICLK_HUMAN; OTTHUMP00000230951.
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MICALCL
交叉反应：Human,
细胞定位：细胞核
ERK2结合睾丸蛋白1抗体产品介绍：background: MICALCL is a 695 amino acid cytoplasmic protein that belongs to the ebitein family and interacts with ERK2 during spermatozoa development. MICALCL contains a polymorphic poly-proline region and is encoded by a gene that maps to human chromosome 11p15.3. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of theERK2结合睾丸蛋白1抗体 WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. Function: May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. SubcellularERK2结合睾丸蛋白1抗体 Location: Cytoplasm. Similarity: Belongs to the ebitein family. Database links: Entrez Gene: 84953 Human Omim: 612355 Human SwissProt: Q6ZW33 Human Unigene: 128196 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ERK2结合睾丸蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 细胞周期蛋白 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid