MICAL3蛋白抗体
规格：1mg/1ml
英文名： MICAL3
别名： MICAL-3; KIAA0819; KIAA1364; MICA3_HUMAN; MICAL 3; Protein MICAL-3.
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MICAL3
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
MICAL3蛋白抗体产品介绍：background: MICAL3 is a 976 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one LIM zinc-binding domain and one calponin-homology domain. Expressed ubiquitously, MICAL3 uses FAD as a cofactor to interact with Rab 1B and, via this interaction, is thought to play a role in spermatid development. MICAL3 exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 22. Chromosome 22 houses over 500 genes, some of which are involved in Phelan-McDermid syndrome, schizophrenia and Neurofibromatosis type 2. Function: Monooxygenase that promotes depolymerization of F-actin by MICAL3蛋白抗体mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process. Subunit: Interacts with RAB1B. Interacts with ERC1 and RAB8A. Subcellular Location: MICAL3蛋白抗体Cytoplasm. Tissue Specificity: Ubiquitous. Similarity: Belongs to the Mical family. Contains 1 CH (calponin-homology) domain. Contains 1 LIM zinc-binding domain. Database links: Entrez Gene: 57553 Human SwissProt: Q7RTP6 Human Unigene: 528024 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MICAL3蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid