MIA40蛋白抗体
规格：1mg/1ml
英文名： MIA40
别名： CHCHD4; Coiled coil helix coiled coil helix domain containing 4; Coiled coil helix coiled coil helix domain containing protein 4; Coiled-coil-helix-coiled-coil-helix domain-containing protein 4; FLJ31
分子量： 16kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
MIA40蛋白抗体**原：KLH conjugated synthetic peptide derived from human MIA40
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat,
细胞定位：
产品介绍：background: CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008] Function: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular MIA40蛋白抗体disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Subcellular Location: Mitochondrion intermembrane space. Tissue Specificity: Expressed in all tissues tested, suggesting an ubiquitous expression. Post-translational modifications: Forms intrachain disulfide bridges, but exists in different MIA40蛋白抗体redox states. Database links: Entrez Gene: 131474 Human Entrez Gene: 72170 Mouse Entrez Gene: 100361898 Rat Entrez Gene: 100364342 Rat Entrez Gene: 312559 Rat Entrez Gene: 445144 Zebrafish Omim: 611077 Human SwissProt: Q8N4Q1 Human SwissProt: Q8VEA4 Mouse SwissProt: Q5BJN5 Rat SwissProt: Q6DEI8 Zebrafish Unigene: 517815 Human Unigene: 41622 Mouse Unigene: 16427 Rat Unigene: 117015 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MIA40蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid