着丝粒蛋白S抗体
规格：1mg/1ml
英文名： MHF1/CENPS
别名： APITD1; Apoptosis-inducing TAF9-like domain-containing protein 1; apoptosis-inducing, TAF9-like domain 1; CENP-S; CENP S; CENPS_HUMAN; Centromere protein S; FAAP16; FANCM-interacting histone fold prot
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MHF1/CEN
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
着丝粒蛋白S抗体产品介绍：background: This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011] Function: DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recorery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. As a component of the APITD1/CENPS complex, is also 着丝粒蛋白S抗体essential for the stable assembly of the outer kinetchore. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Subcellular Location: Nucleus. Chromosome > centromere. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the 着丝粒蛋白S抗体CENPA-NAC complex. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the TAF9 family. Database links: Entrez Gene: 100526739 Human Entrez Gene: 378708 Human Omim: 609130 Human SwissProt: Q8N2Z9 Human Unigene: 412311 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
着丝粒蛋白S抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞周期蛋白 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid