哺乳动物反转录蛋白RTL1抗体
规格：1mg/1ml
英文名： RTL1
别名： Mammalian retrotransposon derived protein 1; Mar1; MART1; Paternally expressed gene 11 protein; PEG11; Retrotransposon derived protein PEG11; Retrotransposon like 1; Retrotransposon like protein 1.
分子量： 155kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RTL1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
哺乳动物反转录蛋白RTL1抗体产品介绍：background: This gene is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009] Function: Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta Subcellular Location: Membrane; Multi-pass membrane protein Database links: Entrez Gene: 388015 Human Omim: 611896 Human SwissProt: A6NKG5 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Rtl1 is one of at least 11 genes called Mar or Mart related to long terminal 哺乳动物反转录蛋白RTL1抗体repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes. RTL1 is an imprinted gene located in a cluster of imprinted genes on chromosome 14. It is expressed from the paternal chromosome and has an antisense transcript with full complementarity to RTL1, RTL1as, expressed from the maternal chromosome, which 哺乳动物反转录蛋白RTL1抗体acts as a repressor for RTL1. Excessive RTL1 expression and decreased RTL1 expression are relevant to upd14pat-like and upd14mat-like phenotypes, respectively. Paternal and maternal uniparental disomy for chromosome 14 (upd14pat and upd14mat) cause distinct phenotypes; Upd14pat results in a unique phenotype characterized by facial abnormality, a small, bell-shaped thorax and abdominal wall defects, and upd14mat leads to pre- and postnatal growth failure and early onset of puberty.
哺乳动物反转录蛋白RTL1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid