S-腺苷蛋氨酸脱羧酶抗体
规格：1mg/1ml
英文名： AMD1/SAMDC
别名： AMD1; S-adenosylmethionine decarboxylase; Adenosylmethionine decarboxylase 1; AdoMetDC; EC 4.1.1.50; FLJ26964; S adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase proenzyme; SamDC
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAMDC
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
S-腺苷蛋氨酸脱羧酶抗体产品介绍：background: The product of this gene is an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low molecular weight aliphatic amines essential for cellular proliferation and tumor promotion. This protein spans 22 kb comprised of 9 exons and 8 introns and encoding two species of mRNA of 2.1 and 3.4-3.6 kb originating from the use of two different polyadenylation signals. The pro protein is an approximate 38.3 kDa which is known to undergo processing at amino acid 68 to yield two fragments of 32 and 6kDa. Post-translational modifications: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine S-腺苷蛋氨酸脱羧酶抗体residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia S-腺苷蛋氨酸脱羧酶抗体and the pyruvoyl group blocking the N-terminus of the alpha chain. Similarity: Belongs to the eukaryotic AdoMetDC family. Gene ID: 262 Database links: Entrez Gene: 262 Human Entrez Gene: 11702 Mouse Entrez Gene: 81640 Rat Omim: 180980 Human SwissProt: P17707 Human SwissProt: P31154 Mouse SwissProt: P17708 Rat Unigene: 159118 Human Unigene: 253533 Mouse Unigene: 56270 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
S-腺苷蛋氨酸脱羧酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid