RSPO4蛋白抗体
规格：1mg/1ml
英文名： RSPO4
别名： C20orf182; CRISTIN4; hRspo4; R-spondin family, member 4; R-spondin-4; Roof plate-specific spondin-4; RSPO4; RSPO4_HUMAN.
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RSPO4
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：分泌型蛋白
RSPO4蛋白抗体产品介绍：background: This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009] Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction withRSPO4蛋白抗体 Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Subcellular Location: Secreted. Post-translational modifications: Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven. DISEASE: Defects in RSPO4 are the cause of anonychia congenita (ANONC) [MIM:206800]. A rare RSPO4蛋白抗体condition characterized by the absence or severe hypoplasia of all fingernails and toenails without significant bone anomalies. Similarity: Belongs to the R-spondin family. Contains 1 FU (furin-like) repeat. Contains 1 TSP type-1 domain. Gene ID: 343637 Database links: Entrez Gene: 343637 Human Entrez Gene: 228770 Mouse Entrez Gene: 499918 Rat Omim: 610573 Human SwissProt: Q2I0M5 Human SwissProt: Q8BJ73 Mouse Unigene: 444980 Human Unigene: 159868 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用RSPO4蛋白抗体：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid