RSPO2蛋白抗体
规格：1mg/1ml
英文名： RSPO2
别名： CRISTIN2; hRspo2; RSPO2_HUMAN; R spondin 2; R spondin 2 homolog; R-spondin 2 homolog (Xenopus laevis); R-spondin family, member 2; Roof plate-specific spondin-2.
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RSPO2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：分泌型蛋白
RSPO2蛋白抗体产品介绍：background: R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008] Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as RSPO2蛋白抗体an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. Subunit: Interacts with WNT1. Binds heparin By similarity. Interacts with LGR4, LGR5 and LGR6. Subcellular Location:RSPO2蛋白抗体 Secreted Similarity: Belongs to the R-spondin family. Contains 1 FU (furin-like) repeat. Contains 1 TSP type-1 domain. Gene ID: 340419 Database links: Entrez Gene: 340419 Human Entrez Gene: 239405 Mouse Entrez Gene: 500863 Rat Omim: 610575 Human SwissProt: Q6UXX9 Human SwissProt: Q8BFU0 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RSPO2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid