RRP4蛋白抗体
规格：1mg/1ml
英文名： RRP4
别名： EXOSC2; Exosome complex exonuclease RRP4; Exosome component 2; hRrp4p; OTTHUMP00000022370; OTTHUMP00000022371; OTTHUMP00000022372; OTTHUMP00000022373; OTTHUMP00000022374; p7; Ribosomal RNA processing
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RRP4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Chimpanzee, Macaque Monkey, Rhesus monkey, Gorilla, Opossum, Marmoset (c
细胞定位：细胞浆
RRP4蛋白抗体产品介绍：background: Rrp4 and Ski7p are components of the cytoplasmic exosome complex, and together with the RNA helicase Ski2p they are necessary for degradation of deadenylated mRNA. Rrp4 is required for the 3’ to 5’ exonuclease activity that produces the 3’ end of the 5.8S rRNA. Rrp4 also functions as a subunit of the specialized trypanosome exosome complex. Function: The exosome, present in both the nucleus and cytoplasm of all eukaryotic cells, is a complex of 3'-5' exoribonucleases containing at least nine core components. Recently, it has been demonstrated, mainly by analyses in yeast, that the nuclear exosome is essential for rRNA processing and sn(o)RNA biogenesis. Furthermore, it is involved in the degradation of improperly processed mRNAs. The cytoplasmic exosome participates in normal RRP4蛋白抗体mRNA turnover and in the degradation of inherently instable mRNAs that contain AU-rich elements. Therefore, the exosome plays a key role in RNA metabolism. Subcellular Location: Cytoplasmic, Exosome and Nuclear Similarity: Belongs to the RRP1 family. Database linksRRP4蛋白抗体: Entrez Gene: 615712 Cow Entrez Gene: 608606 Dog Entrez Gene: 101126796 Gorilla Entrez Gene: 23404 Human Entrez Gene: 100397822 Marmoset (common) Entrez Gene: 227715 Mouse Entrez Gene: 100439017 Orangutan Entrez Gene: 595050 Xenopus tropicalis GenBank: NP_055100.2 Human Omim: 602238 Human SwissProt: Q2KID0 Cow SwissProt: Q13868 Human SwissProt: Q8VBV3 Mouse Unigene: 654643 Huma Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RRP4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid