RREB1蛋白抗体
规格：1mg/1ml
英文名： RREB1
别名： FINB; Finger protein in nuclear bodies; Hindsight homolog; HNT; LZ321; Raf responsive zinc finger protein LZ321; Raf-responsive zinc finger protein LZ321; RAS responsive element binding protein 1; Ras
分子量： 184kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RREB1
交叉反应：Human, Mouse, Rat,
RREB1蛋白抗体细胞定位：细胞核
产品介绍：background: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] Function: Transcription factor that binds specifically toRREB1蛋白抗体 the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Subcellular Location: Nucleus speckle. Tissue Specificity: Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs toRREB1蛋白抗体 the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Database links: Entrez Gene: 6239 Human Entrez Gene: 68750 Mouse Omim: 602209 Human SwissProt: Q92766 Human SwissProt: Q3UH06 Mouse Unigene: 298248 Human Unigene: 132634 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产RREB1蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid