垂体肿瘤转化基因抗体
规格：1mg/1ml
英文名： Securin
别名： AW555095; C87862; Cut2; EAP 1; EAP1; ESP1 ASSOCIATED PROTEIN 1; Esp1-associated protein; hPTTG; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pitu
分子量： 22-28kDa
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储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTTG1
垂体肿瘤转化基因抗体交叉反应：Human, Mouse, Rat, Pig, Horse,
细胞定位：细胞核 细胞浆
产品介绍：background: The encoded protein is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]. Function: Expressed at low level in垂体肿瘤转化基因抗体 most tissues, except in ***** testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Phosphorylated at Ser-165 by CDK1 during mitosis. Phosphorylated in vitro by ds-DNA kinase. Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase 垂体肿瘤转化基因抗体UBE2C/UBCH10. Similarity: Belongs to the securin family. Gene ID: 9232 Database links: Entrez Gene: 9232 Human Entrez Gene: 30939 Mouse Entrez Gene: 64193 Rat Omim: 604147 Human SwissProt: O95997 Human SwissProt: Q6IAL9 Human SwissProt: Q3Y5K4 Mouse SwissProt: Q5SRU0 Mouse SwissProt: Q9CQJ7 Mouse SwissProt: P97613 Rat Unigene: 350966 Human Unigene: 6856 Mouse Unigene: 137183 Rat Unigene: 271 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 垂体肿瘤转化基因PTTG可在多种肿瘤组织及部分正常组织细胞内表达较垂体肿瘤转化基因抗体高,对促进细胞增殖、转化及肿瘤发生有重要作用。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞周期蛋白 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid