代谢型谷氨酸受体5B抗体
规格：1mg/1ml
英文名： MGLUR5B
别名： Glutamate receptor, metabotropic 5; GPRC1E; GRM5; metabotropic glutamate receptor 5; Metabotropic glutamate receptor 5 variant F; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate re
分子量： 130kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MGLUR5B
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Sheep, Monkey,
细胞定位：细胞膜
代谢型谷氨酸受体5B抗体产品介绍：background: Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals. Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers代谢型谷氨酸受体5B抗体 signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Subunit: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity). Subcellular Location: Cell Membrane 代谢型谷氨酸受体5B抗体Similarity: Belongs to the G-protein coupled receptor 3 family. Gene ID: 2915 Database links: Entrez Gene: 2915 Human Entrez Gene: 108071 Mouse Entrez Gene: 24418 Rat Omim: 604102 Human SwissProt: P41594 Human SwissProt: Q3UVX5 Mouse SwissProt: P31424 Rat Unigene: 147361 Human Unigene: 29972 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
代谢型谷氨酸受体5B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid