MEGF11蛋白抗体
规格：1mg/1ml
英文名： MEGF11
别名： KIAA1781; MEG11_HUMAN; Megf11; Multiple EGF-like domains protein 11; multiple EGF-like-domains 11; Multiple epidermal growth factor-like domains 11; Multiple epidermal growth factor-like domains prote
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MEGF11
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat,
细胞定位：细胞膜
MEGF11蛋白抗体产品介绍：background: MEGF11 is a 1,044 amino acid single-pass type I membrane protein that belongs to the MEGF family. MEGF11 exists as a homopolymer that primarily localizes to protruding lamellipodia in an irregular, mosaic-like adhesion pattern. Expressed at high levels in ***** and fetal brain and ***** spinal cord, MEGF11 is found at lower levels in kidney, ovary and heart. MEGF11 contains fourteen EGF-like domains, one EMI domain, and undergoes alternative splicing events to produce four isoforms. The gene encoding MEGF11 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. Function: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell typeMEGF11蛋白抗体 evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note: Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localizeMEGF11蛋白抗体 with MEGF10. Similarity: Belongs to the MEGF family. Contains 14 EGF-like domains. Contains 1 EMI domain. Database links: Entrez Gene: 84465 Human Entrez Gene: 214058 Mouse Entrez Gene: 691517 Rat Entrez Gene: 563468 Zebrafish Omim: 612454 Human SwissProt: A6BM72 Human SwissProt: Q80T91 Mouse Unigene: 712886 Human Unigene: 127721 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MEGF11蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid