过氧化还原酶3抗体
规格：1mg/1ml
英文名： PRDX3
别名： peroxiredoxin 3; peroxiredoxin3; peroxiredoxin-3; Antioxidant Protein 1; AOP 1; AOP1; HBC189; MER 5; MER5; MGC104387; MGC24293; Mitochondrial thioredoxin dependent peroxide reductase; Peroxiredoxin3;
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PRDX3
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞浆 线粒体
过氧化还原酶3抗体产品介绍：background: The Peroxiredoxin (Prdx, Prx, or Trx-Px) family of enzymes is a recently identified family of peroxidases found in free-living organisms. The six known isoforms (Prx1-6) play an important role in protecting lipids, enzymes and DNA against peroxides, such as hydrogen peroxide. The ubiquitously expressed peroxiredoxins have also been shown to play a role in apoptosis and cell differentiation. This is acomplished by the active cysteine of Prx reducing peroxides, which is then converted into a transient cysteine sulfenic acid or cysteine sulfinic acid. If Prx protection is inadequate against peroxidases, the resulting protein and DNA damage may result in neurological disease such as Alzheimer's or DNA damage leading to cancer. Function: Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Subunit:过氧化还原酶3抗体 Dodecameric ring assembled from homodimeric units; disulfide-linked, upon oxidation. The rings have an approximate diameter of 150 A and a central hole of 70 A. 3-5% of the rings are interlocked by pairs. Binds MAP3K13. Interacts with NEK6. Interacts with LRRK2. Subcellular Location: Mitochondrion. Post-translational modifications: Phosphorylated by LRRK2; phosphorylation reduces perodixase activity. Similarity: Belongs to the AhpC/TSA family. Contains 1 thioredoxin domain. Gene ID: 10935 Database links: Entrez Gene: 281998 Cow Entrez Gene: 10935 Human Entrez 过氧化还原酶3抗体Gene: 11757 Mouse Entrez Gene: 64371 Rat Omim: 604769 Human SwissProt: P35705 Cow SwissProt: P30048 Human SwissProt: P20108 Mouse SwissProt: Q9Z0V6 Rat Unigene: 523302 Human Unigene: 29821 Mouse Unigene: 2011 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
过氧化还原酶3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 染色质和核信号 激酶和磷酸酶 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid