脯氨酸水解酶4抗体
规格：1mg/1ml
英文名： P4HTM
别名： Transmembrane prolyl 4-hydroxylase; Proline hydrolase 4; proline 4-hydroxylase; P4htm; hypoxia-inducible factor prolyl 4-hydroxylase; P4H-TM; HIF-prolyl hydroxylase PH-4; P4HTM_HUMAN; Hypoxia-inducibl
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PH-4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
脯氨酸水解酶4抗体产品介绍：background: The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Subunit: Homodimer. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Tissue Specificity: Widely expressed with highest levels in ***** pancreas, heart, skeletal 脯氨酸水解酶4抗体muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.脯氨酸水解酶4抗体 Post-translational modifications: Glycosylated. Similarity: Contains 2 EF-hand domains. Contains 1 Fe2OG dioxygenase domain. Gene ID: 54681 Database links: Entrez Gene: 538626 Cow Entrez Gene: 54681 Human Entrez Gene: 74443 Mouse Entrez Gene: 301008 Rat SwissProt: Q9NXG6 Human SwissProt: Q8BG58 Mouse Unigene: 654944 Human Unigene: 226534 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脯氨酸水解酶4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid