活化转录因子7相互作用蛋白2抗体
规格：1mg/1ml
英文名： MCAF2
别名： 4930558K11Rik; Activating transcription factor 7-interacting protein 2; ATF7 interacting protein 2; Atf7ip2; BC018510; FLJ12668; Get 1; MBD1-containing chromatin-associated factor 2; MCAF2; MCAF2_HUMA
分子量： 76kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MCAF2
交叉反应：Human, Mouse,
细胞定位：细胞核
活化转录因子7相互作用蛋白2抗体产品介绍：background: MCAF2 is a 682 amino acid nuclear protein that exists as two alternatively spliced isoforms. MCAF2 can act as either an activator or repressor, thereby modulating chromatin formation and/or transcription regulation by linking transcription factors to transcription apparatuses. A member of the MCAF family, MCAF2 contains one fibronectin type-III domain and is thought to form a complex with ESET and MBD1. The gene encoding MCAF2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome活化转录因子7相互作用蛋白2抗体 is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably 活化转录因子7相互作用蛋白2抗体by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity Subunit: Interacts with MBD1, SETDB1 and SP1. Probably forms a complex with SETDB1 and MBD1. Subcellular Location: Nucleus. Similarity: Belongs to the MCAF family. Contains 1 fibronectin type-III domain. Database links: Entrez Gene: 80063 Human Entrez Gene: 75329 Mouse Omim: 613645 Human SwissProt: Q5U623 Human SwissProt: Q3UL97 Mouse Unigene: 513343 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
活化转录因子7相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid