甲基化CpG结合蛋白3抗体
规格：1mg/1ml
英文名： MBD3
别名： AI181826; AU019209; MBD 3; Mbd3; MBD3: methyl CpG binding domain protein 3; MBD3_HUMAN; Methyl CpG binding domain protein 3; Methyl CpG binding protein MBD3; Methyl-CpG-binding domain protein 3; Methy
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MBD3
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核
甲基化CpG结合蛋白3抗体产品介绍：background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple甲基化CpG结合蛋白3抗体 transcript variants of this gene. [provided by RefSeq, Jul 2013] Function: Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Subunit: Heterodimer with MBD2. Part of the NuRD and the MeCP1 complex. Interacts with BCL6, HDAC1, MTA2, DNMT1, p66-alpha and p66-beta. Subcellular Location: Nucleus.甲基化CpG结合蛋白3抗体 Chromosome. Note: Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes. Similarity: Contains 1 MBD (methyl-CpG-binding) domain. Gene ID: 53615 Database links: Entrez Gene: 53615 Human Entrez Gene: 17192 Mouse Entrez Gene: 362834 Rat Entrez Gene: 398135 Xenopus laevis Omim: 603573 Human SwissProt: O95983 Human SwissProt: Q9Z2D8 Mouse Unigene: 178728 Human Unigene: 7142 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甲基化CpG结合蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid