去甲基化酶MBD2抗体
规格：1mg/1ml
英文名： MBD2
别名： Demethylase; DMTase; MBD 2; Mbd2; MBD2_HUMAN; MBD2a; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY CO 4
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MBD2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Xenopus laevis
细胞定位：细胞核
去甲基化酶MBD2抗体产品介绍：background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] Function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine 去甲基化酶MBD2抗体within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. Subcellular Location: Nucleus. Nuclear, in discrete foci. Detected at replication foci in late S phase. Tissue Specificity: Highly expressed in brain, heart, kidney, stomach, testis and placenta. Similarity: 去甲基化酶MBD2抗体Contains 1 MBD (methyl-CpG-binding) domain. Gene ID: 8932 Database links: Entrez Gene: 8932 Human Entrez Gene: 17191 Mouse Entrez Gene: 680172 Rat Entrez Gene: 399118 Xenopus laevis Omim: 603547 Human SwissProt: Q9UBB5 Human SwissProt: Q9Z2E1 Mouse Unigene: 25674 Human Unigene: 322 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
去甲基化酶MBD2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid