诎畏哂关丝氨攉/苏氨攉汰酶2
规格：1mg/1ml
英文名： MAST2
别名： EC 2.7.11.1 3; FLJ39200; KIAA0807; MAST 2; MAST 205; Mast2; MAST2_HUMAN; Microtubule associated serine/threonine kinase 2; Microtubule associated testis specific serine/threonine protein kinase; Micro
分子量： 196kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAST2
交叉反应：Human, Mouse,
细胞定位：细胞浆
诎畏哂关丝氨攉/苏氨攉汰酶2产品介绍：background: MAST205 is a testis-specific, cytoplasmic protein that functions in a multi-protein complex in the maturation of spermatids. MAST205 is involved in linking the dystrophin/utrophin network with microtubule filaments via Syntrophin. By forming a complex with TRAF6, MAST205 regulates lipopolysaccharide-induced IL-12 synthesis in macrophages. This leads to the inhibition of TRAF6 NF-ⅹB activation. Two isoforms exist for MAST205 due to alternative splicing. Isoform 1 represents the full length protein, while isoform 2 lacks the residues 327-396 and 1091-1113. The N-terminus of MAST205 must be phosphorylated in order for ubiquitination to occur at the same site. This ubiquitination leads to the degradation of MAST205 via proteasome-mediated proteolysis. Function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a 诎畏哂关丝氨攉/苏氨攉汰酶2complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation Subunit: Interacts with CDHR2. Tissue Specificity: Abundant in the testis. Post-translational modifications: Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination. Similarity: Belongs to the诎畏哂关丝氨攉/苏氨攉汰酶2 protein kinase superfamily. AGC Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 PDZ (DHR) domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 23139 Human Entrez Gene: 17776 Mouse Omim: 612257 Human SwissProt: Q6P0Q8 Human SwissProt: Q60592 Mouse Unigene: 319481 Human Unigene: 9287 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
诎畏哂关丝氨攉/苏氨攉汰酶2产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid