MARCKS样蛋白1抗体
规格：1mg/1ml
英文名： MARCKSL1
别名： F52; Mac MARCKS; Mac-MARCKS; MacMARCKS; Macrophage enriched Myristoylated Alanine Rich C Kinase Substrate Like Protein; Macrophage myristoylated alanine-rich C kinase substrate; MARCKS like 1; MARCKS
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MARCKSL1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
MARCKS样蛋白1抗体产品介绍：background: This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012] Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. Subunit: Binds to filamentous actin MARCKS样蛋白1抗体(F-actin), but not to monomeric G-actin, independently of its phosphorylation status. Subcellular Location: Cytoplasm By similarity. Cell membrane Post-translational modifications: Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8 Similarity: Belongs to the MARCKS family. Gene ID: 65108 Database links: Entrez Gene: 65108 Human Entrez Gene: 17357 MARCKS样蛋白1抗体Mouse Entrez Gene: 100366048 Rat Entrez Gene: 81520 Rat Omim: 602940 Human SwissProt: P49006 Human SwissProt: P28667 Mouse SwissProt: Q9EPH2 Rat Unigene: 707012 Human Unigene: 75061 Human Unigene: 424974 Mouse Unigene: 2486 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MARCKS样蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid