微管关联蛋白RP/EB家族成员1抗体
规格：1mg/1ml
英文名： MAPRE1
别名： 5530600P05Rik; Adenomatous polyposis coli binding protein EB 1; Adenomatous polyposis coli binding protein EB1; AI462499; AI504412; APC binding protein EB 1; APC binding protein EB1; APC-binding prote
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAPRE1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow,
细胞定位：细胞浆
微管关联蛋白RP/EB家族成员1抗体产品介绍：background: The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008] Function: May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at 微管关联蛋白RP/EB家族成员1抗体centrosomes. May play a role in cell migration. Subcellular Location: Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the MAPRE family. Contains 1 CH (calponin-homology) domain. Contains 1微管关联蛋白RP/EB家族成员1抗体 EB1 C-terminal domain. Gene ID: 22919 Database links: Entrez Gene: 22919 Human Entrez Gene: 419288 Chicken Entrez Gene: 13589 Mouse Entrez Gene: 100173206 Orangutan Entrez Gene: 114764 Rat Omim: 603108 Human SwissProt: Q5ZLC7 Chicken SwissProt: Q15691 Human SwissProt: Q61166 Mouse SwissProt: Q5R7Z5 Orangutan SwissProt: Q6V291 Quail SwissProt: Q66HR2 Rat Unigene: 472437 Human Unigene: 143877 Mouse Unigene: 7652 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
微管关联蛋白RP/EB家族成员1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid