纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体
规格：1mg/1ml
英文名： SerpinB2
别名： Serpin B2; Serpinb2; SerpinB2; plasminogen activator inhibitor 2; HsT1201; Monocyte Arg serpin; Monocyte Arg-serpin; PAI2A; PAI; PAI-2; PAI 2; PAI2; Placental plasminogen activator inhibitor; PAI2_RAT
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAI-2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞浆 细胞外基质 分泌型蛋白
纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体产品介绍：background: SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin. SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, 纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence. Function: 纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体Inhibits urokinase-type plasminogen activator. Subunit: Interacts with PSMB1. Subcellular Location: Cytoplasm. Secreted, extracellular space. Post-translational modifications: The signal sequence is not cleaved. Similarity: Belongs to the serpin family. Ov-serpin subfamily. Gene ID: 5055 Database links: Entrez Gene: 5055 Human Entrez Gene: 18788 Mouse Omim: 173390 Human SwissProt: P05120 Human SwissProt: P12388 Mouse Unigene: 594481 Human Unigene: 271870 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
纤溶酶原激活物抑制因子2/血浆酶原激活酶抑制因子-2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid