转录因子MAFG抗体
规格：1mg/1ml
英文名： MAFG
别名： AA545192; Basic leucine zipper transcription factor MafG; C630022N07Rik; hMAF; MAFG; MAFG v maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian); MAFG_HUMAN; MGC13090; MGC20149; RP23 84C12.9
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAFG
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig,
细胞定位：细胞核
转录因子MAFG抗体产品介绍：background: Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010] Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins转录因子MAFG抗体 heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+). Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in skeletal muscle. Also expressed in heart and brain. Post-translational modifications: Acetylated in erythroid cells by CREB-binding protein (CBP). Acetylation augments the DNA-binding activity of NFE2, but has no转录因子MAFG抗体 effect on binding NFE2. Sumoylation at Lys-14 is required for active transcriptional repression. Similarity: Belongs to the bZIP family. Maf subfamily. Contains 1 bZIP domain. Database links: Entrez Gene: 769355 Chicken Entrez Gene: 515219 Cow Entrez Gene: 4097 Human Entrez Gene: 17134 Mouse Entrez Gene: 64188 Rat Omim: 602020 Human SwissProt: Q90889 Chicken SwissProt: A5PJV0 Cow SwissProt: O15525 Human SwissProt: O54790 Mouse SwissProt: Q76MX4 Rat Unigene: 252229 Human Unigene: 268010 Mouse Unigene: 292957 Mouse Unigene: 393664 Mouse Unigene: 17361 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子MAFG抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid