MAD4蛋白抗体
规格：1mg/1ml
英文名： MAD4
别名： bHLHc12; Class C basic helix loop helix protein 12; Class C basic helix-loop-helix protein 12; MAD 4; MAD4; Mad4 homolog; MAD4_HUMAN; Max associated protein 4; Max dimerization protein 4; Max dimerize
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAD4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig, Cat,
细胞定位：细胞核
MAD4蛋白抗体产品介绍：background: This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]MAD4蛋白抗体Function: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. Subcellular Location: Nucleus. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Database links: Entrez Gene: 10608 Human Entrez Gene: MAD4蛋白抗体17122 Mouse Entrez Gene: 360961 Rat SwissProt: Q14582 Human SwissProt: Q60948 Mouse Unigene: 102402 Human Unigene: 655020 Human Unigene: 259260 Mouse Unigene: 391777 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MAD4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid