MAD3蛋白抗体
规格：1mg/1ml
英文名： MAD3
别名： bHLHc13; Class C basic helix-loop-helix protein 13; FLJ35523; Likely ortholog of mouse Max dimerization protein 3; MAD3_HUMAN; MAX dimerization protein 3; Max dimerizer 3; Max-associated protein 3; Ma
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAD3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Cat,
细胞定位：细胞核
MAD3蛋白抗体产品介绍：background: This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008] Function: MAD3蛋白抗体Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. Subcellular Location: Nucleus. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Database links: Entrez Gene: 83463 Human Entrez Gene: 17121 Mouse MAD3蛋白抗体Entrez Gene: 252915 Rat Entrez Gene: 394031 Zebrafish Omim: 609450 Human SwissProt: Q9BW11 Human SwissProt: Q80US8 Mouse SwissProt: Q62912 Rat SwissProt: Q7SX95 Zebrafish Unigene: 726161 Human Unigene: 20350 Mouse Unigene: 10214 Rat Unigene: 84919 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MAD3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid