轴突导向因子1抗体
规格：1mg/1ml
英文名： Netrin 1
别名： Netrin-1; Netrin1; Netrin 1; Ntn 1; NTN 1L; Ntn1; Ntn-1; NTN1L; Unc6.
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NtN1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
细胞定位：细胞外基质 分泌型蛋白
轴突导向因子1抗体产品介绍：background: Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008] Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the轴突导向因子1抗体 initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis. Subunit: Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Widely expressed in normal ***** tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Similarity轴突导向因子1抗体: Contains 3 laminin EGF-like domains. Contains 1 laminin N-terminal domain. Contains 1 NTR domain. Gene ID: 9423 Database links: Entrez Gene: 9423 Human Entrez Gene: 18208 Mouse Entrez Gene: 114523 Rat Omim: 601614 Human SwissProt: O95631 Human SwissProt: O09118 Mouse SwissProt: Q924Z9 Rat Unigene: 128002 Human Unigene: 660885 Human Unigene: 39095 Mouse Unigene: 41052 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Netrin-1是与层粘连蛋白相关的、高度保守的小分子分泌蛋白家族成员的一种。
轴突导向因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid