磷酸化星形胶质细胞升高基因1抗体
规格：1mg/1ml
英文名： phospho-LYRIC (Ser568)
别名： LYRIC (phospho S568); p-LYRIC (phospho S568); 3D3; 3D3/LYRIC; AEG 1; AEG-1; AEG1; Astrocyte elevated gene 1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; LYRIC_HUMAN; Lysine rich CEACAM1 assoc
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞核 细胞浆 细胞膜
磷酸化星形胶质细胞升高基因1抗体产品介绍：background: LYRIC is a type II membrane protein, the precise role of which has yet to be defined. It is expressed in breast and prostate carcinoma and is a potential mediator of lung metastasis. It has also been found in mouse Purkinje neurons and cerebellum. In epithelial cells it is recruited to tight junctions (TJ) during the maturation of the TJ complexes. LYRIC co-localizes with beta-catenin in normal and tumour tissues. Function: Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis,磷酸化星形胶质细胞升高基因1抗体 possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. Subunit: Interacts with BCCIP, CREBBP/CBP and RELA/p65. Subcellular Location: Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in 磷酸化星形胶质细胞升高基因1抗体various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme. Gene ID: 92140 Database links: Entrez Gene: 92140 Human Entrez Gene: 509788 Cow Entrez Gene: 67154 Mouse Entrez Gene: 170910 Rat Omim: 610323 Human SwissProt: Q86UE4 Human SwissProt: Q80WJ7 Mouse SwissProt: Q9Z1W6 Rat Unigene: 377155 Human Unigene: 130883 Mouse Unigene: 6864 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化星形胶质细胞升高基因1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid