LYPD3蛋白抗体
规格：1mg/1ml
英文名： LYPD3
别名： 1600019D15Rik; 2310061G07Rik; C4.4A; FLJ10525; GPI-anchored metastasis-associated protein C4.4A homolog; GPI-anchored metastasis-associated protein homolog; Ly6/PLAUR domain-containing protein 3; Lypd
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LYPD3
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞膜
LYPD3蛋白抗体产品介绍：background: LYPD3 is a 346 amino acid cell membrane protein that supports cell migration. Implicated in tumor progression and urothelial cell-matrix interactions, LYPD3 is expressed in skin, urothelium and placenta, with weak levels found in peripheral blood mononuclear cells and esophagus. Upregulated in migrating keratinocytes, LYPD3 undergoes post-translational N- and O-glycosylation, and contains two UPAR/Ly6 domains. The gene encoding LYPD3 maps to human chromosome 19q13.31. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fc receptors (FcRs). Function: Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved inLYPD3蛋白抗体 tumor progression. Subunit: Binds laminin-1 and laminin-5. Interacts with LGALS3 By similarity. Interacts with AGR2 and AGR3. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell LYPD3蛋白抗体carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers. Post-translational modifications: N-glycosylated and O-glycosylated. Similarity: Contains 2 UPAR/Ly6 domains. Gene ID: 27076 Database links: Entrez Gene: 27076 Human Omim: 609484 Human SwissProt: O95274 Human Unigene: 631594 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LYPD3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid