LYNX1蛋白抗体
规格：1mg/1ml
英文名： LYNX1
别名： Ly-6/neurotoxin-like protein 1; Ly6/neurotoxin 1; LYNX1; LYNX1_HUMAN; Secreted Ly6/uPAR related protein 2; SLURP2.
分子量： 12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LYNX1
交叉反应：Human,
细胞定位：细胞膜
LYNX1蛋白抗体产品介绍：background: This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). In brain, isoform 2 modulates functional properties of nAChRs to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha4beta2 nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha4beta2 nAChRs ByLYNX1蛋白抗体 similarity. Prevents plasticity in the primary visual cortex late in life By similarity. In keratinocytes, isoform 3 delays differentiation and prevents apoptosis. Subunit: Isoform 2 interacts with nAChRs, including alpha4beta2 (CHRNA4/CHRNB2) and alpha7 (CHRNA7) By similarity. Competes with alpha-bungarotoxin for nAChR alpha7 binding. Isoform 3 may interact with heteropentameric nAChRs expressed by keratinocytes. Subcellular Location: Cell membrane. Tissue Specificity: Isoform 3 is expressed at highest levels in cervix and esophagus, followed by ***** and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. In the epidermis,LYNX1蛋白抗体 predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level). Up-regulated 3-fold in psoriatic lesional skin. Detected in serum (at protein level). Similarity: Contains 1 UPAR/Ly6 domain. Gene ID: 66004 Database links: Entrez Gene: 66004 Human Entrez Gene: 23936 Mouse Entrez Gene: 300018 Rat Omim: 606110 Human SwissProt: Q9BZG9 Human SwissProt: Q9WVC2 Mouse Unigene: 158665 Human Unigene: 257067 Mouse Unigene: 32045 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LYNX1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞膜受体 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid