结节漏斗肽TIP39抗体
规格：1mg/1ml
英文名： TIP39/Tuberoinfundibular peptide
别名： TIP39; TIPF39; Tuberoinfundibular peptide of 39 residues.
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIP39/Tu
交叉反应：Human, Mouse, Dog, Cow,
细胞定位：分泌型蛋白
结节漏斗肽TIP39抗体产品介绍：background: Tuberoinfundibular peptide of 39 residues (TIP39) was initially identified as a neurotransmitter and agonist of the PTH2 receptor, which is expressed in the cardiovascular system. Accumulating evidence suggests that TIP39 may be the endogenous ligand of the parathyroid hormone 2 receptor. The vast majority of TIP39 containing neurons are localized in two regions, the subparafascicular area at the thalamic midbrain junction, and the medial paralemniscal nucleus in the rostral pons. In contrast to the restricted localization of TIP39 containing cell bodies, TIP39 containing fibers have a widespread distribution. Function: Plays a role as a potent and selective 结节漏斗肽TIP39抗体agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Subunit: Ligand of high affinity for the PTH2 receptor结节漏斗肽TIP39抗体 (PTH2R). Subcellular Location: Secreted Tissue Specificity: Highly expressed in fetal and ***** brain, cerebellum and trachea. Weakly expressed in spinal cord, fetal liver, kidney and heart. Similarity: Belongs to the parathyroid hormone family. Database links: Entrez Gene: 113091 Human Entrez Gene: 114640 Mouse SwissProt: Q96A98 Human SwissProt: Q91W27 Mouse Unigene: 339845 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
结节漏斗肽TIP39抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid