磷脂酰肌醇-5-磷酸盐-4激酶2型α抗体
规格：1mg/1ml
英文名： PIP5K2
别名： phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1 phosphatidylinositol 4 phosphate 5 kinase 2 alpha; 1 phosphatidylinositol 4 phosphate 5 kinase; 1 phosphatidylinositol 4 phosphate kinase; 1-p
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIPF39
交叉反应：Human, Mouse, Rat, Chicken, Cow,
细胞定位：细胞核 细胞浆 细胞膜
磷脂酰肌醇-5-磷酸盐-4激酶2型α抗体产品介绍：background: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] Function: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of 磷脂酰肌醇-5-磷酸盐-4激酶2型α抗体cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. Subunit: Subcellular Location: Cell membrane By similarity. Nucleus. Cytoplasm. Note: May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor 磷脂酰肌醇-5-磷酸盐-4激酶2型α抗体cells in response to light By similarity. Localization to the nucleus is modulated by the interaction with PIP4K2B. Tissue Specificity: Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. Similarity: Contains 1 PIPK domain. Database links: Entrez Gene: 420504 Chicken Entrez Gene: 533289 Cow Entrez Gene: 5305 Human Entrez Gene: 18718 Mouse Entrez Gene: 116723 Rat Omim: 603140 Human SwissProt: Q5F356 Chicken SwissProt: P48426 Human SwissProt: O70172 Mouse SwissProt: Q9R0I8 Rat Unigene: 57079 Human Unigene: 313977 Mouse Unigene: 24177 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷脂酰肌醇-5-磷酸盐-4激酶2型α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid