细胞核酸结合蛋白抗体
规格：1mg/1ml
英文名： CNBP/ZNF9
别名： CCHC type zinc finger nucleic acid binding protein; Cellular nucleic acid binding protein; Cellular nucleic acid-binding protein; CNBP; CNBP_HUMAN; CNBP1; DM2; Erythroid differentiation related; PROMM
分子量： 19kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CNBP/ZNF
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, Monkey,
细胞定位：细胞浆
细胞核酸结合蛋白抗体产品介绍：background: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression. Subcellular Location: Cytoplasm. Endoplasmic reticulum. Tissue Specificity: Present in all tissues examined. DISEASE: Defects in CNBP are the cause of dystrophia myotonica type 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). A multisystem disease细胞核酸结合蛋白抗体 characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene. Similarity: Contains 7 CCHC-type zinc细胞核酸结合蛋白抗体 fingers. Gene ID: 7555 Database links: Entrez Gene: 7555 Human Entrez Gene: 395731 Chicken Entrez Gene: 504831 Cow Entrez Gene: 12785 Mouse Entrez Gene: 64530 Rat Entrez Gene: 399294 Xenopus laevis Omim: 116955 Human SwissProt: O42395 Chicken SwissProt: Q3T0Q6 Cow SwissProt: P62633 Human SwissProt: P53996 Mouse SwissProt: P62634 Rat Unigene: 518249 Human Unigene: 290251 Mouse Unigene: 6187 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞核酸结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid