锌指蛋白259抗体
规格：1mg/1ml
英文名： ZNF259/ZPR1
别名： MGC110983; Zinc finger protein 259; Zinc finger protein ZPR1; ZNF 259; ZNF259; ZPR1; ZPR1_HUMAN.
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZNF259/Z
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
锌指蛋白259抗体产品介绍：background: ZPR1 is a zinc finger-containing protein that is capable of binding to the intracellular tyrosine kinase domain of the epidermal growth factor receptor. Stimulation of mammalian cells with epidermal growth factor reduces ZPR1 affinity for the EGFR and leads to an accumulation of the protein in the nucleus. The ZPR1 zinc finger is necessary for its association with the EGFR. Function: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O(2)-induced neuronal cell death. Subunit: Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum By similarity. Interacts with锌指蛋白259抗体 elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor. Subcellular Location: Cytoplasm. Nucleus > nucleolus. Translocates to the nucleolus after treatment with mitogens. Tissue Specificity: Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the锌指蛋白259抗体 cerebellum. DISEASE: May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration (Ref.7). Disruption phenotype Die during early embryonic development. Embryos show growth delay, failed to form normal trophectoderm and to expand the inner cell mass. Similarity: Belongs to the ZPR1 family. Gene ID: 8882 Database links: Entrez Gene: 8882 Human Entrez Gene: 22687 Mouse Entrez Gene: 500989 Rat Omim: 603901 Human SwissProt: O75312 Human SwissProt: Q62384 Mouse Unigene: 7165 Human Unigene: 17519 Mouse Unigene: 102011 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白259抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid