中期因子/肝素结合生长因子抗体
规格：1mg/1ml
英文名： Midkine
别名： Amphiregulin associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; MK 1; MK; MK1; NEGF 2; NEGF2; neurite growth promoting factor 2; Neurite outgrowth promoting protein; MK_HUMAN.
分子量： 13.4kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Midkine
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Fruit Fly,
细胞定位：分泌型蛋白
中期因子/肝素结合生长因子抗体产品介绍：background: Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines. Function: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase中期因子/肝素结合生长因子抗体 (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). Subunit: Homodimer. Interacts with ALK. Subcellular Location: Secreted. Similarity: Belongs to the pleiotrophin family. Gene ID: 4192 Database links: Entrez Gene: 280852 Cow Entrez 中期因子/肝素结合生长因子抗体Gene: 4192 Human Entrez Gene: 17242 Mouse Entrez Gene: 81517 Rat Omim: 162096 Human SwissProt: P21741 Human SwissProt: P12025 Mouse SwissProt: Q9R1S9 Rat Unigene: 21528 Cow Unigene: 82045 Human Unigene: 906 Mouse Unigene: 17447 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 中期因子(midkine, MK)具有多种生物学功能: 可促进神经轴突 的生长和各种胚胎神经元的存活,做为一种有丝分裂原,与肿瘤的发生密切相关，MK还有较强的 促血管生成特性, 经研究证实, MK可促进内皮细胞增殖并 提高血管的密度，在多种肿瘤中期因子/肝素结合生长因子抗体组织和肿 瘤患者的血清中的水平都明显升高。MK和多向促**(p leiotro2 phin, PTN)同属于一类新的结合肝素的生长因子家 族。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid