肝脏X受体α+肝脏X受体β抗体
规格：1mg/1ml
英文名： LXR alpha + LXR beta
别名： Liver X receptor alpha; Liver X receptor alpha; Liver X receptor beta; LXR a; LXR; LXR b; LXRa; LXRalpha; LXRb; LXRbeta; NER; NERI; NR1H2; NR1H3; Nuclear orphan receptor LXR alpha; Nuclear orphan rece
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LXR alph
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Xenopus laevis
细胞定位：细胞核
肝脏X受体α+肝脏X受体β抗体产品介绍：background: LXR alpha and LXR beta are orphan receptors. Interaction with RXR shifts RXR from its role as a silent DNA binding partner to an active ligand binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4 type response elements characterized by direct repeats of two similar hexanuclotide half sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis. LXR alpha: Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals. LXR beta: Ubiquitously expressed. Function: Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt 肝脏X受体α+肝脏X受体β抗体spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Subcellular Location: Nuclear Gene ID: 10062 7376 Database links: Entrez Gene: 395221 Chicken Entrez Gene: 507176 Cow Entrez Gene: 10062 Human Entrez Gene: 7376 Human 肝脏X受体α+肝脏X受体β抗体Entrez Gene: 22259 Mouse Entrez Gene: 397553 Pig Entrez Gene: 58852 Rat Omim: 602423 Human SwissProt: Q5E9B6 Cow SwissProt: P55055 Human SwissProt: Q13133 Human SwissProt: Q91X41 Mouse SwissProt: Q9Z0Y9 Mouse SwissProt: Q5I035 Rat SwissProt: Q62685 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝脏X受体α+肝脏X受体β抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞膜受体 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid