肝脏X受体β抗体
规格：1mg/1ml
英文名： LXR beta
别名： Liver X nuclear receptor beta; Liver X receptor beta; Liver X receptor beta; LX receptor beta; LXR b; LXR beta; LXRB; NER 1; NER; NER I; NER1; NERI; NR1H 2; NR1H; NR1H2; NR1H2 protein; NR1H2_HUMAN; Nu
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LXR beta
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞核
肝脏X受体β抗体产品介绍：background: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by 肝脏X受体β抗体OMIM, Jan 2010] Function: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination 肝脏X受体β抗体of LDLR, VLDLR and LRP8. Subunit: Forms a heterodimer with RXR. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 7376 Database links: Entrez Gene: 7376 Human Entrez Gene: 58851 Rat Omim: 600380 Human SwissProt: P55055 Human SwissProt: Q62755 Rat Unigene: 432976 Human Unigene: 786 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝脏X受体β抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞膜受体 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid