白三烯C4合成酶抗体
规格：1mg/1ml
英文名： LTC4S
别名： Leukotriene C(4) synthase; leukotriene C4 synthase; LTC4 synthase.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LTC4S
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
白三烯C4合成酶抗体产品介绍：background: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008] Function: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. Subunit: Homotrimer. Interacts with ALOX5AP and ALOX5. Subcellular Location: Nucleus outer membrane;白三烯C4合成酶抗体 Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Tissue Specificity: Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets. DISEASE: LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. Similarity:白三烯C4合成酶抗体 Belongs to the MAPEG family. Database links: Entrez Gene: 4056 Human Entrez Gene: 17001 Mouse Entrez Gene: 114097 Rat Omim: 246530 Human SwissProt: Q16873 Human SwissProt: Q60860 Mouse SwissProt: Q925U2 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白三烯C4合成酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid