LSM11蛋白抗体
规格：1mg/1ml
英文名： LSM11
别名： 2210404M20Rik; LSM11 homolog, U7 small nuclear RNA associated; LSM11, U7 small nuclear RNA associated; U7 snRNA-associated Sm-like protein LSm11.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LSM11
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
LSM11蛋白抗体产品介绍：background: LSM11 is a 39.5 kDa protein that is a component of a specialized SMN complex also containing Lsm10. Lsm11 not only specifies the assembly of the U7 Sm core but also fulfills an important role in U7 snRNP-mediated histone mRNA processing. Function: Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing By similarity. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA. Subunit: Component of the heptameric ring U7 snRNP complex, or U7 LSM11蛋白抗体Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Interacts with LSM10, SMN, SNRPB and ZNF473. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 By similarity. Interacts (via the Sm domains) with CLNS1A. Interacts with PRMT5 LSM11蛋白抗体and WDR77 Subcellular Location: Nuclear Post-translational modifications: Not methylated Similarity: Belongs to the snRNP Sm proteins family. Gene ID: 134353 Database links: Entrez Gene: 134353 Human Entrez Gene: 72290 Mouse SwissProt: P83369 Human SwissProt: Q5SUH5 Mouse SwissProt: Q8BUV6 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LSM11蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid