LSM1蛋白抗体
规格：1mg/1ml
英文名： LSM1
别名： Cancer associated Sm like protein; Cancer associated Sm-like; Cancer-associated Sm-like; CASM; LSM1; LSM1; ; LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Lsm1 protein; LSM1_HUMAN; Sm
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LSM1
交叉反应：Human, Mouse, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
LSM1蛋白抗体产品介绍：background: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011] Function: Plays a role in LSM1蛋白抗体replication-dependent histone mRNA degradation. Binds specifically to the 3'-terminal U-tract of U6 snRNA. Subunit: Interacts with SLBP. Interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a doughnut shape. Subcellular Location: Nucleus. Tissue Specificity: Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.LSM1蛋白抗体 Similarity: Belongs to the snRNP Sm proteins family. Gene ID: 27257 Database links: Entrez Gene: 27257 Human Entrez Gene: 67207 Mouse Entrez Gene: 364624 Rat Omim: 607281 Human SwissProt: O15116 Human SwissProt: Q8VC85 Mouse Unigene: 425311 Human Unigene: 30198 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LSM1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞类型标志物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid