富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体
规格：1mg/1ml
英文名： LRRK1
别名： KIAA1790; Leucine rich repeat serine/threonine protein kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK 1; Lrrk1; LRRK1_HUMAN; RIPK6; Roco1.
分子量： 225kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRRK1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体细胞定位：细胞浆
产品介绍：background: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2,038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体 the pathogenesis of Parkinson's disease. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. Contains 4 ANK repeats. Contains 13 LRR (leucine-rich) repeats. Contains 1 protein 富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体kinase domain. Contains 1 Roc domain. Gene ID: 79705 Database links: Entrez Gene: 79705 Human Entrez Gene: 233328 Mouse Entrez Gene: 308703 Rat Omim: 610986 Human SwissProt: Q38SD2 Human SwissProt: Q3UHC2 Mouse Unigene: 407918 Human Unigene: 33284 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 细胞凋亡 G蛋白偶联受体 细胞分化 G蛋白信号 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid