富含亮氨酸重复蛋白52抗体
规格：1mg/1ml
英文名： LRRC52
别名： FLJ25811; Leucine rich repeat containing 52; Leucine-rich repeat-containing protein 52; LRC52_HUMAN; Lrrc52.
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRRC52
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
富含亮氨酸重复蛋白52抗体产品介绍：background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome富含亮氨酸重复蛋白52抗体 are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium富含亮氨酸重复蛋白52抗体. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties. Subunit: May interact with KCNU1; this interaction may be required for LRRC52 stability and may change the channel gating properties By similarity. Interacts with KCNMA1. Subcellular Location: Membrane. Tissue Specificity: Mainly expressed in testis and skeletal muscle. Similarity: Contains 5 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. Gene ID: 440699 Database links: Entrez Gene: 440699 Human Entrez Gene: 289199 Rat SwissProt: Q8N7C0 Human SwissProt: A0JN28 Rat Unigene: 664975 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：富含亮氨酸重复蛋白52抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid