TGF-β诱导早期应答基因1抗体
规格：1mg/1ml
英文名： KLF10
别名： TIEG1; TGF-beta inducible early growth response gene 1; Transforming growth factor-beta-inducible early growth response protein 1; Krueppel-like factor 10; TIEG-1; EGR-alpha; KLF10; TIEG; GDNF-inducib
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIEG1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
TGF-β诱导早期应答基因1抗体产品介绍：background: KLF10 is a transcription factor that plays a role in the regulation of cell growth. It binds to the consensus sequence 5'-GGTGTG-3'. KLF10 plays a role in the response to TGFbeta (through the TGFbeta/Smad signalling pathway) and estrogen. In both cases, KLF10 induces or repressed gene transcription to enhance the TGFbeta/Smad signalling pathway, as well as other pathways, to regulate cell proliferation, differentiation and apoptosis. KLF10 has been shown to have a role in skeletal disease (osteopenia/osteoporosis), hypertrophic cardiomyopathy, and breast and prostate cancer. Function: Transcriptional repressorTGF-β诱导早期应答基因1抗体 involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Subcellular Location: Nucleus. Post-translational modifications: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation TGF-β诱导早期应答基因1抗体(Probable). Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers. Gene ID: 7071 Database links: Entrez Gene: 7071 Human Entrez Gene: 21847 Mouse Entrez Gene: 81813 Rat Omim: 601878 Human SwissProt: Q13118 Human SwissProt: O89091 Mouse SwissProt: O08876 Rat Unigene: 435001 Human Unigene: 4292 Mouse Unigene: 2398 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TGF-β诱导早期应答基因1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 细胞凋亡 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid