富含亮氨酸重复蛋白33抗体
规格：1mg/1ml
英文名： LRRC33
别名： ELLP3030; GARPL1; NRROS_HUMAN; Leucine rich repeat containing protein 33; Lrcc33; UNQ3030.
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LRRC33
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞膜
富含亮氨酸重复蛋白33抗体产品介绍：background: LRRC33 is a 692 amino acid protein that contains 17 LRR repeats. The gene encoding LRRC33 maps to chromosome 3, which encodes over 1,100 genes. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Marfan syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3. Function: Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex. May play a critical role in富含亮氨酸重复蛋白33抗体 desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. Subunit: Interacts with CYBB/NOX2; the interaction is direct By similarity. Interacts (via LRR repeats) with TLR2, TLR3, TLR4, 富含亮氨酸重复蛋白33抗体TLR9 and probably other Toll-like receptors. Subcellular Location: Membrane; Single pass type I membrane protein. Tissue Specificity: Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen. Similarity: Contains 21 LRR (leucine-rich) repeats. Gene ID: 375387 Database links: Entrez Gene: 375387 Human Entrez Gene: 224109 Mouse Entrez Gene: 303875 Rat SwissProt: Q86YC3 Human SwissProt: Q8BMT4 Mouse SwissProt: Q5BK65 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸重复蛋白33抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid